Like Night and Day Rods and Cones Have Different Pigment Regeneration Pathways
نویسنده
چکیده
Sustained vision requires continuous regeneration of visual pigments in rod and cone photoreceptors by the 11-cis-retinal chromophore. In this issue of Neuron, Mata et al. report a novel enzymatic pathway uniquely designed to keep up with the high demand for cone pigment regeneration in bright light and to preclude rods from utilizing chromophore produced in daylight, when rods are not very useful for vision.
منابع مشابه
Effects of Orcadian Rhythm and cAMP on Retinomotor Movements in the Green Sunfish, Lepomis cyanellus
The photoreceptors and retinal pigmented epithelium (RPE) of teleosts undergo diurnal changes in position in response to day/night changes in light conditions. These position changes, called retinomotor movements, may also persist under conditions of constant darkness. In this study, the authors have compared the retinomotor movements of rods, cones, and RPE under conditions of constant darknes...
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The photoreceptors and retinal pigmented epithelium (RPE) of teleosts undergo diurnal changes in position in response to day/night changes in light conditions. These position changes, called retinomotor movements, may also persist under conditions of constant darkness. In this study, the authors have compared the retinomotor movements of rods, cones, and RPE under conditions of constant darknes...
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Retinas of adult teleost fish can regenerate after injury. Two important issues regarding this phenomenon are the assembly of the regenerated retina and the neuronal images of the visual scene that the regenerated retina produces. Here we report experiments in which the visual pigment content of photoreceptors derived from native and regenerated sunfish retinas was determined by microspectropho...
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KEY POINTS This study explores the molecular mechanisms that regulate the recycling of chromophore required for pigment regeneration in mammalian cones. We report that two chromophore binding proteins, retinol dehydrogenase 8 (RDH8) and photoreceptor-specific ATP-binding cassette transporter (ABCA4) accelerate the dark adaptation of cones, first, directly, by facilitating the processing of chro...
متن کاملLate stages of visual pigment photolysis in situ: Cones vs. rods
Slow photolysis reactions and the regeneration of the dark pigment constitute the mechanisms of dark adaptation whereby photoreceptor cells restore their sensitivity after bright illumination. We present data on the kinetics of the late stages of the photolysis of the visual pigment in intact rods and red- and green-sensitive cones of the goldfish retina. Measurements were made on single photor...
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ورودعنوان ژورنال:
- Neuron
دوره 36 شماره
صفحات -
تاریخ انتشار 2002